GnRH antagonists have important differences in their PK profiles

The currently available GnRH antagonists have important differences in their PK profiles. This may have important implications in how they need to be taken – see their respective Summary of Product Characteristics for more information^1,2

“Drug half-life has important implications for dosing regimen and peak-to-trough ratio at the steady state…a half life of 12-48h is generally ideal for once-daily dosing of oral drugs. If the half-life is too short, it may require more dosing…”³

Smith D et al. J Med Chem 2018³